Bio Serum Firm

Your skin used to feel tight and full. Now it feels a little looser. You notice it most in photos. That’s your collagen slowing down. The good news? You can wake it back up.

Bio Serum Firm is a growth factor serum for firming aging skin. It uses human growth factors and peptides to tell your skin cells to rebuild. More collagen. More elastin. More hydration. Results start in as little as 6 days.

This is not a basic serum. Neocutis made it with processed skin proteins. These are the same proteins your skin uses to heal itself naturally.

Is This You?

• Your skin used to snap back. Now it just feels loose and tired.
• You look fine in the mirror but older in photos — less defined, less lifted.
• Your foundation settles into lines it didn’t used to.
• You’ve tried serums that smell great but don’t actually do anything.
• You want something that works at the cellular level — not just on the surface.
• You’re in your 40s and feel like your skin aged faster than you expected.

If any of that sounds familiar, this is the serum we recommend first.

Key Ingredients

• Human Growth Factors (PSP): Tell your skin cells to make more collagen and hold more moisture. This keeps skin full and firm.
• Proprietary Peptides: Block a protein that speeds up aging. Less of that protein means your skin acts younger.
• Sodium Hyaluronate: Pulls water into your skin. Fine lines look softer. Skin feels plump.
• Pullulan: Gives skin an instant tightening effect. Also helps the other ingredients work better.
• Acetyl Glucosamine: A gentle sugar that fades sun damage and evens skin tone over time.
• Arginine + Glutamine: Amino acids that protect skin and help build collagen faster.

Why We Love It

• One of the only serums with both human growth factors AND peptides in one daily formula
• Most patients feel a difference by day 6 — smoother, tighter, more hydrated
• By week 8, 94% saw better texture and 92% saw brighter skin (clinical data)
• Safe for all skin types — even sensitive and acne-prone
• No fragrance, no parabens, not tested on animals
• Works even better when paired with your in-office treatments
• You’re investing in the structure of your skin — not just the surface

How to Use

Apply a small amount to clean skin. Cover your face, neck, and chest. Use morning and/or evening. Let it absorb. Then apply your moisturizer. Use it twice a day for best results. Skin keeps improving past the first week.

Size

1 fl. oz. / 30 mL

Skin Type / Who It’s For

All skin types, including sensitive and acne-prone. Great for anyone seeing early signs of aging — loose skin, fine lines, dullness, or rough texture. Best for ages 35+ or anyone who wants to protect their collagen now.

Pairs Well With

Treatments:

• MOXI™ Laser Skin Rejuvenation — growth factors accelerate post-laser repair and maximize your results
• Pixel8 Radiofrequency Microneedling — supports deep collagen remodeling triggered by RF microneedling
• Radiesse® — a powerful combination for rebuilding lost volume and skin structure from the inside out
• Ultherapy® — use daily at home to maintain and extend the lifting and tightening results from your Ultherapy treatment

Products:

• NEOCUTIS® Lumière Firm Eye Cream — bring the same growth factor firming technology to the delicate eye area for a full-face approach to aging
• The C Complex — layer vitamin C in the morning before Bio Serum Firm to brighten, protect, and boost collagen synthesis
• The Gold Standard Retinol — use in the evening to accelerate cell turnover while growth factors rebuild underneath

Learn More

See the science at Neocutis